Identifying Combinations of Cancer Drivers in Individual Patients
作者： Michael I. Klein , Vincent L. Cannataro , Jeffrey P. Townsend , David F. Stern , Hongyu Zhao
DOI: 10.1101/674234
关键词:
摘要: Identifying the subset of genetic alterations present in individual tumors that are essential and collectively sufficient for cancer initiation progression would advance development effective personalized treatments. We CRSO inferring combinations alterations, i.e., rules, cooperate to drive tumor formation patients. prioritizes rules by integrating patient-specific passenger probabilities along with information about recurrence particular throughout population. examples glioma, liver melanoma significant differences patient outcomes based on rule assignments not identifiable consideration alterations.
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