Important role of indels in somatic mutations of human cancer genes

摘要: Cancer is clonal proliferation that arises owing to mutations in a subset of genes confer growth advantage. More and more cancer related are found have accumulated somatic mutations. However, little has been reported about mutational patterns insertions/deletions (indels) these genes. We analyzed indels' abundance distribution, the relative ratio between indels base substitutions association those two forms large number Catalogue Somatic Mutations database. strong correlation cancer-related showed they tend concentrate at same locus coding sequences within samples. importantly, much higher proportion were observed mutations, as compared meiotic ones. Furthermore, our analysis demonstrated great diversity some loci Particularly with abundant 3n oncogenes 7.9 times than tumor suppressor There three distinct indel distribution mutations: high proportion, non-random distribution. Because influence on gene function (e.g., effect frameshift mutation), indicate frequently under positive selection can often be 'driver mutations' oncogenesis. Such driver forces better explain why less while genes, because their different These findings contribute understanding relationship cancer.