Mycolyl glycolipids stimulate macrophages to release a chemotactic factor.

摘要: We have previously reported that mycolyl glycolipids from Nocardia rubra such as glucose or trehalose mycolates induced granuloma formation in mice [1,2]. The structure of the carbohydrate moiety influenced forming activity profoundly. Here, we examined macrophage-chemotactic culture supernatants stimulated with various differing (trehalose 6,6′-dimycolate, TDM; monomycolate, GM; mannose MM; and fructose FM). A distinctive chemotactic was detected TDM GM, but little none MM FM.