Factor V Leiden, prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and homocysteinemia in Tunisian blood donors.
作者： Samira Hadhri , Mohamed Ben Rejab , Hajer Guedria , Lamia Ifa , Noureddine Chatti
DOI: 10.1002/JCLA.21506
关键词:
摘要: Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This basis varies widely between ethnic groups. We investigated the distribution four inherited polymorphisms in 113 unselected Tunisian blood donors by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The allele frequencies Factor V Leiden (FVL), prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 677C>T, and MTHFR 1298A>C mutations were 3, 0.9, 30, 31%, respectively. 677C>T was influenced age. Twenty-nine demonstrated more than one markers. Hyperhomocysteinemia found 12 subjects, it statistically 677TT genotype. Principal component analysis allowed disclosing resemblance Mediterranean populations. Our findings may helpful for population genetics study, provide epidemiologic database further studies thrombosis field among Tunisians.
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