Population genetics of venous thromboembolism. A narrative review.

摘要: Results from epidemological studies are consistent with the hypothesis that disparities in venous thromboembolism (VTE) burden attributable to differences genetic structure among populations different backgrounds. To end, recent have demonstrated not only potential associations between certain alleles and VTE but also clear distribution of these patients stratified by ancestry. There a number notable clinical pathophysiological questions arise findings. First at all is defining precise variant(s) alter disease susceptibility. The comparatively lower rates recorded Asians would imply risk profile devoid many factors on comparison Caucasian or African counterparts putative protective factor advocated former population. Identification variants provided specific insight into selected shed lights biology disease. association observed ancestry likely be multifactorial, possibly reflecting, addition variation, socioeconomic differences. Acknowledgment this may provide useful information biomedical contexts help identify individual for VTE.