Effects of insulin and 2-deoxy-D-glucose on plasma glucose level and lateral hypothalamic eating threshold in the rat☆

摘要: Abstract Thresholds for elicited eating through monopolar electrodes in the perifornical region of lateral hypothalamus and plasma glucose concentration were determined over periods several hours, while blood levels cellular utilization altered by means forced feeding hypothalamic stimulation, subcutaneous insulin injections and/or intraperitonneal 2-deoxy-D-glucose injections. Forced resulted increased thresholds eating, whereby tail vein was positively correlated to these thresholds. A subsequent, long-lasting, severe insulin-hypoglycemia not sufficient normalize such elevated However, doses 100–250 mg/kg, after an initial increase, decreased 90 min injection. When combined so as balance contrary glycemic effects, effect dominated, resulting slightly increasing thesholds. The results are discussed terms recently suggested hypothesis that regulates entry into glucosensitive systems ventromedial hypothalamus, thus generates satiety signals rather than hunger.