Development of a novel aerosol generation system for conducting inhalation exposures to ambient particulate matter (PM).

摘要: In this study, we developed a novel method for generating aerosols that are representative of real-world ambient particulate matter (PM) in terms both physical and chemical characteristics, with the ultimate objective using them inhalation exposure studies. The protocol included collection PM on filters high-volume sampler, which were then extracted ultrapure Milli-Q water vortexing sonication. As an alternative approach collection, particles directly captured into aqueous slurry samples versatile aerosol concentration enrichment system (VACES)/aerosol-into-liquid collector tandem technology. from protocols re-aerosolized commercially available nebulizers. characteristics (i.e., particle size distribution) generated examined by means scanning mobility sizer (SMPS) connected to condensation counter (CPC) at different compressed air pressures nebulizer, dilution flow rates. addition, collected (both re-aerosolized) chemically analyzed water-soluble organic carbon (WSOC), elemental (EC/OC), inorganic ions, polycyclic aromatic hydrocarbons (PAHs), metals trace elements. Using filter extracts, able effectively recover components (e.g., matter, ions); however, was deficient recovering some important insoluble such as EC, PAHs, many redox-active elements metals. contrast, VACES/aerosol-into-liquid technology collecting slurry, preserve water-insoluble very effectively. These results illustrate superiority VACES/aerosol-into liquid be used conjunction re-aerosolization setup create fully represent PM, making it attractive choice application