Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles

摘要: Air pollution (AirP) is associated with many neurodevelopmental and neurological disorders in human populations. Rodent models show similar neurotoxic effects of AirP particulate matter (PM) collected by different methods or from various sources. However, controversies continue on the identity specific components mechanisms neurotoxicity. We urban PM two modes at same site time: direct collection as an aqueous slurry (sPM) versus a nano-sized sub-fraction PM0.2 that was eluted filters (nPM). The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) depleted >50% bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, other organic compounds. Three biological were used: vivo exposure adult male mice to re-aerosolized sPM for 3 weeks, gestational exposure, glial cell cultures. In contrast larger inflammatory responses vitro, cerebral cortex largely overlapped exposures. Adult brain included induction IFNγ NF-κB. Gestational caused equivalent depressive behaviors. Responses diverged glutamate receptor mRNA, systemic fat gain insulin resistance. shared toxic may arise transition organics. contrast, but not nPM, decreased glutamatergic mRNAs, which be attributed PAHs. discuss potential overlap between despite major differences bulk chemical composition.