Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
作者： Berenice A Benayoun , Sandrine Caburet , Aurélie Dipietromaria , Adrien Georges , Barbara d'Haene
DOI: 10.1371/JOURNAL.PONE.0008789
关键词:
摘要: Background The somatic mutation in the FOXL2 gene c.402C>G (p.Cys134Trp) has recently been identified vast majority of adult ovarian granulosa cell tumors (OGCTs) studied. In addition, this seems to be specific OGCTs and is likely a driver malignant transformation. However, its pathogenic mechanisms remain elusive.
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