Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival

摘要: Aim There is debate as to the correct treatment algorithm sequence for patients with locally advanced rectal cancer liver metastases. The aim of study was assess safety, resectability and survival after a modified 'liver-first' approach. Method This retrospective undergoing preoperative radiotherapy primary tumour, followed by resection and, finally, tumour. Short-term surgical outcome, overall recurrence-free are reported. Results Between 2009 2013, 45 underwent radiotherapy. Thirty-four (76%) received neoadjuvant chemotherapy, 24 (53%) concomitant chemotherapy during 17 (43%) adjuvant chemotherapy. median time interval from last fraction surgery 21 (range 7-116) 60 31-156) days, respectively. Rectal performed in 42 but not one patient complete response two progressive metastatic disease. After three did proceed planned second stage (n = 2) or lung 1) due Clavien-Dindo ≥Grade III complications developed 6.7% 19% resection. who completed 40) were 49.7 13.0 months, Twenty 30 recurrence further curative intent. Conclusion liver-first approach safe efficient allows initial control both tumour