Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
作者： Georg Kraal , Manolis Pasparakis , Monique N. Vergouwe , Klaus Rajewsky , Menno P.J. de Winther
DOI: 10.1172/JCI18580
关键词:
摘要: Atherosclerosis is now generally accepted as a chronic inflammatory condition. The transcription factor NF-κB is a key regulator of inflammation, immune responses, cell survival, and …
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sci-hub.st 参考文章(33)
Sandra A. Schreyer, Cynthia M. Vick, Renée C. LeBoeuf, Loss of lymphotoxin-α, but not tumor necrosis factor-α reduces atherosclerosis in mice Journal of Biological Chemistry. ,vol. 277, pp. 12364- 12368 ,(2002) , 10.1074/JBC.M111727200
B.E. Clausen, C. Burkhardt, W. Reith, R. Renkawitz, I. Förster, Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Research. ,vol. 8, pp. 265- 277 ,(1999) , 10.1023/A:1008942828960
David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti, Alan Aderem, The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature. ,vol. 401, pp. 811- 815 ,(1999) , 10.1038/44605
Roland Lang, Robert L. Rutschman, David R. Greaves, Peter J. Murray, Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. Journal of Immunology. ,vol. 168, pp. 3402- 3411 ,(2002) , 10.4049/JIMMUNOL.168.7.3402
Wendy L. HENDRIKS, Hans van der BOOM, Leonie C. van VARK, Louis M. HAVEKES, LIPOPROTEIN LIPASE STIMULATES THE BINDING AND UPTAKE OF MODERATELY OXIDIZED LOW-DENSITY LIPOPROTEIN BY J774 MACROPHAGES Biochemical Journal. ,vol. 314, pp. 563- 568 ,(1996) , 10.1042/BJ3140563
Tucker Collins, Myron I. Cybulsky, NF-κB: pivotal mediator or innocent bystander in atherogenesis? Journal of Clinical Investigation. ,vol. 107, pp. 255- 264 ,(2001) , 10.1172/JCI10373
Menno P.J. de Winther, Marion J.J. Gijbels, Ko Willems van Dijk, Patrick J.J. van Gorp, Hiroshi Suzuki, Tatsuhiko Kodama, Rune R. Frants, Louis M. Havekes, Marten H. Hofker, Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis. ,vol. 144, pp. 315- 321 ,(1999) , 10.1016/S0021-9150(98)00332-3
Amer A. Beg, William C. Sha, Roderick T. Bronson, Sankar Ghosh, David Baltimore, Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature. ,vol. 376, pp. 167- 170 ,(1995) , 10.1038/376167A0
U P Steinbrecher, J L Witztum, S Parthasarathy, D Steinberg, Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 7, pp. 135- 143 ,(1987) , 10.1161/01.ATV.7.2.135
Marc Schmidt-Supprian, Wilhelm Bloch, Gilles Courtois, Klaus Addicks, Alain Israël, Klaus Rajewsky, Manolis Pasparakis, NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti Molecular Cell. ,vol. 5, pp. 981- 992 ,(2000) , 10.1016/S1097-2765(00)80263-4