Trabeculated Right Ventricular Free Wall in the Chicken Heart Forms by Ventricularization of the Myocardium Initially Forming the Outflow Tract

摘要: Recent molecular lineage analyses in mouse have demonstrated that the right ventricle is recruited from anterior mesoderm later stages of cardiac development. This contrast to current views development chicken heart, which suggest initial heart tube contains a subset ventricular precursors. We investigated fate outflow tract myocardium using immunofluorescent staining myocardium, and tracer, as well cell death experiments. These showed initially myocardial its entirety, increasing length up HH24. The subsequently, shortens result ventricularization, contributing trabeculated free wall, infundibulum, ventricle. During this shortening, overall maintained because formation nonmyocardial portion between distal border pericardial reflections. Cell transdifferentiation were found play more limited contribution shortening than generally appreciated, if they any part at all. death, nonetheless, plays an important role disappearance collar continues invest aorta pulmonary trunk around HH30, separation intrapericardial arterial vessels. Taken together, we show, opposed some beliefs, pole similar mammals birds.