Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

摘要: Abstract Efficient engulfment of the intact cell corpse is a critical end point apoptosis, required to prevent secondary necrosis and inflammation. The presentation "eat-me" signals on dying an important part this process recognition by professional phagocytes. Here, we present evidence that apoptotic cells secrete chemotactic factor(s) stimulate attraction monocytic primary macrophages. activation caspase-3 in was found be for release factor(s). putative chemoattractant identified as phospholipid, lysophosphatidylcholine. Further analysis showed lysophosphatidylcholine released from due mediated calcium-independent phospholipase A 2 . These data suggest addition eat-me signals, display ensure efficient removal postapoptotic necrosis.