The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease.

摘要: An array of studies implicate different classes protease and their endogenous inhibitors in multiple sclerosis (MS) pathogenesis based on expression patterns MS lesions, sera, and/or cerebrospinal fluid (CSF). Growing evidence exists regarding mechanistic roles inflammatory neurodegenerative aspects this disease. Proteolytic events participate demyelination, axon injury, apoptosis, development the response including immune cell activation extravasation, cytokine chemokine activation/inactivation, complement activation, epitope spreading. The potential significance proteolytic activity to therefore relates not only use as important biomarkers disease activity, but additionally prospective therapeutic targets. Experimental data indicate that understanding net physiological consequence altered levels progression necessitates context substrates, inhibitors, cascade interactions, which together make up degradome. This review will focus physiologic role those families already identified markers MS; is, metallo-, serine, cysteine proteases.