Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients.

摘要: The implication of cytochrome P450 CYP2D6 enzyme activity in the metabolism antipsychotic drug risperidone has been reported vitro and studies healthy volunteers. Around 7 % Caucasians have inherited impaired capacity this (poor metabolisers). These subjects might be prone to higher plasma concentrations risperidone. aim study was determine relationship between debrisoquine metabolic ratio (MR), a marker activity, levels psychiatric patients. A population 40 Spanish Hungarian schizophrenic patients studied. possible inhibition also evaluated subgroup co-medicated with inhibitors CYP2D6. risperidone/9-hydroxy-risperidone correlated significantly MR (p < 0.001). In strong CYP2D6, 0.05) 0.01) were compared monotherapy. According present data, evaluation may reflect actual Therefore, use help assess potential pharmacokinetic interactions improve treatment.