Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing

摘要: Purpose: To illustrate the utility of CYP450 genotyping to guide clinical psychopharmacological treatment decisions and minimize or avoid harmful costly adverse drug reactions (ADRs). Data sources: DNA was extracted from a whole blood sample case study subject tested for gene polymorphisms in CLIA certified Laboratory Personalized Health at Genomas, Inc. Clinical data were obtained patient records clinician observations. Conclusions: We present which ascertainment multiple isoenzyme deficiencies resulted dramatic change psychotropic approach. Shortly after making these adjustments, saw significant improvement most her debilitating psychiatric symptoms. Implications practice: In complex cases, testing can pharmacotherapy by exposing innate hepatic metabolic as result polymorphism. such clinicians favor treatments that target functional pathways rather than deficient null thus leading decreased risk ADRs improved response.