Physiogenomic method for predicting drug metabolism reserve for antidepressants and stimulants

作者: Mohan Ranjit Kumar Kocherla , Andreas Windemuth , Gualberto Ruano , David Victor Villagra , John W. Goethe

DOI:

关键词:

摘要: Disclosed herein are compositions and methods relevant to a novel Drug Metabolism Reserve Physiotype determine the metabolic capacity of human individual. The allows determination innate patient antidepressant stimulant treatment can be predicted diagnosed simply from blood sample. In disclosed method, an individual is genotyped for plurality polymorphisms in gene encoding CYP2C9, CYP2C19 CYP2D6, genotypes used produce four indices, which relate

参考文章(10)
Godfrey Pearlson, Mohan Kocherla, Andreas Windemuth, Harold I. Schwartz, Gualberto Ruano, John W. Goethe, Yaraliz Aleman, Bruce Bower, C. Lee Blair, Somatic complications of psychotropic medications in a patient with multiple CYP2 drug metabolism deficiencies Connecticut medicine. ,vol. 71, pp. 197- 200 ,(2007)
Laureano Progenika Biopharma S.A. S.A. Simón Buela, Diego Progenika Biopharma S.A. Tejedor Hernández, Antonio Progenika Biopharma S.A. Martínez Martínez, Marta Progenika Biopharma S.A. Artieda Oseñalde, Lorena Progenika Biopharma S.A. Hernández García, Elise Progenika Biopharma S.A. Jiménez Uribe, Monica Progenika Biopharma S.A. López Martínez, Methods and products for in vitro genotyping ,(2006)
Joan Landino, Jane Buckley, John M. Roy, David Villagra, Krystyna Gorowski, Mohan Kocherla, Andreas Windemuth, Gualberto Ruaño, Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing Journal of the American Academy of Nurse Practitioners. ,vol. 23, pp. 459- 463 ,(2011) , 10.1111/J.1745-7599.2011.00640.X
Dennis J. O'Kane, John L. Black, David A. Mrazek, Methods for selecting medications ,(2004)
Gualberto Ruaño, David Villagra, Bonnie Szarek, Andreas Windemuth, Mohan Kocherla, Krystyna Gorowski, Christopher Berrezueta, Harold I Schwartz, John Goethe, Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients Biomarkers in Medicine. ,vol. 5, pp. 439- 449 ,(2011) , 10.2217/BMM.11.33
David Villagra, John Goethe, Harold I Schwartz, Bonnie Szarek, Mohan Kocherla, Krystyna Gorowski, Andreas Windemuth, Gualberto Ruaño, Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes Biomarkers in Medicine. ,vol. 5, pp. 427- 438 ,(2011) , 10.2217/BMM.11.32
Gualberto Ruaño, David Villagra, Umme Salma Rahim, Andreas Windemuth, Mohan Kocherla, Bruce Bower, Bonnie L Szarek, John W Goethe, Increased carrier prevalence of deficient CYP2C9, CYP2C19 and CYP2D6 alleles in depressed patients referred to a tertiary psychiatric hospital. Personalized Medicine. ,vol. 5, pp. 579- 587 ,(2008) , 10.2217/17410541.5.6.579