Pretreatment with an intravenous lipid emulsion increases plasma eicosapentanoic acid and downregulates leukotriene b4, procalcitonin, and lymphocyte concentrations after open heart surgery in infants.
作者： John E. Van Aerde , Ari R. Joffe , Michael T. Clandinin , Bodil M. K. Larsen , Catherine J. Field
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摘要: Background: The effect of providing a lipid emulsion containing medium-chain triglyceride (MCT), soybean oil, and fish oil in critically ill infants is not widely studied. This study investigated effects on plasma phospholipids immune biomarkers. Materials Methods: Thirty-two undergoing cardiopulmonary bypass (CPB) dependent parenteral nutrition (PN) were randomized to receive either (control, n = 16) or 50:40:10 mixture MCT, (treatment, 16). PN was administered for 3 days preoperatively 10 postoperatively. Fatty acids, procalcitonin (PCT), leukotriene B4 (LTB4), lymphocytes quantified at baseline, before surgery, 1, 7 after surgery. Results: PCT significantly lower the treatment vs control group 1 day postoperatively (P .01). exhibited ω-6 ω-3 ratio .0001) higher concentration all postoperative periods .001). Treatment ...
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