Ion channels in the regulation of apoptosis

摘要: Apoptosis, a type of genetically controlled cell death, is fundamental cellular mechanism utilized by multicellular organisms for disposal cells that are no longer needed or potentially detrimental. Given the crucial role apoptosis in physiology, deregulation apoptotic machinery associated with various diseases as well abnormalities development. Acquired resistance to represents common feature most and perhaps all types cancer. Therefore, repairing reactivating promising strategy fight Accumulated evidence identifies ion channels essential regulators apoptosis. However, contribution specific varies greatly depending on type, channel intracellular localization, pathology signaling pathways involved. Here we discuss involvement major regulation. This article part Special Issue entitled: Membrane transporters cancers.