Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure
作者： Edward A. Ratovitski
DOI: 10.1016/J.FEBSLET.2015.04.020
关键词:
摘要: This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx tongue affect the expression members necroptotic pathway CYLD, RIPK1, MLKL. Different degrees protein interaction between signaling intermediates were also observed SCC sensitive or to cisplatin. Modulation RIPK1 with miR-101-3p mimic inhibitor, as well siRNA, chemical inhibitors was shown sensitivity is first report showing modulatory effect ΔNp63α-responsive on tumor variably responding platinum chemotherapy.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(38)
Julie Reyjal, Kevin Cormier, Sandra Turcotte, Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapies. Advances in Experimental Medicine and Biology. ,vol. 772, pp. 167- 188 ,(2014) , 10.1007/978-1-4614-5915-6_8
Xinfang Yu, Qipan Deng, Wei Li, Lanbo Xiao, Xiangjian Luo, Xiaolan Liu, Lifang Yang, Songling Peng, Zhihui Ding, Tao Feng, Jian Zhou, Jia Fan, Ann M. Bode, Zigang Dong, Jikai Liu, Ya Cao, Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production Oncotarget. ,vol. 6, pp. 1995- 2008 ,(2015) , 10.18632/ONCOTARGET.3038
Yiping Huang, Rafael Guerrero-Preston, Edward A. Ratovitski, Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation Cell Cycle. ,vol. 11, pp. 1247- 1259 ,(2012) , 10.4161/CC.11.6.19670
Sarah J. Seitz, Elisa Schulze Schleithoff, Andreas Koch, André Schuster, Andreas Teufel, Frank Staib, Wolfgang Stremmel, Gerry Melino, Peter H. Krammer, Tobias Schilling, Martina Müller, Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway International Journal of Cancer. ,vol. 126, pp. 2049- 2066 ,(2010) , 10.1002/IJC.24861
F Basit, S Cristofanon, S Fulda, Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes Cell Death & Differentiation. ,vol. 20, pp. 1161- 1173 ,(2013) , 10.1038/CDD.2013.45
Xinbing Sui, Lijun Jin, Xuefeng Huang, Shumin Geng, Chao He, Xiaotong Hu, p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy. ,vol. 7, pp. 565- 571 ,(2011) , 10.4161/AUTO.7.6.14073
D Lu, J R Delaney, J Axelrod, M D Potter, M Vamos, V Wong, N D P Cosford, R Xiang, D G Stupack, K E McCabe, K Bacos, Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma Cell Death and Disease. ,vol. 5, ,(2014) , 10.1038/CDDIS.2014.448
Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth, Christina Eftychi, Juan Lin, Teresa Corona, Nicole Hermance, Matija Zelic, Petra Kirsch, Marijana Basic, Andre Bleich, Michelle Kelliher, Manolis Pasparakis, RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis Nature. ,vol. 513, pp. 90- 94 ,(2014) , 10.1038/NATURE13608
Barry Trink, Motonobu Osada, Edward A. Ratovitski, David Sidransky, p63 Transcriptional Regulation of Epithelial Integrity and Cancer Cell Cycle. ,vol. 6, pp. 240- 245 ,(2007) , 10.4161/CC.6.3.3803
Simone Fulda, Therapeutic exploitation of necroptosis for cancer therapy. Seminars in Cell & Developmental Biology. ,vol. 35, pp. 51- 56 ,(2014) , 10.1016/J.SEMCDB.2014.07.002