General Stress Response

摘要: Induction of the general stress response by one affords significant cross-protection against other stresses. Activation σB initiates primary and secondary events that collectively bring about response. The diverse stresses which elicit activity fall into two classes: (i) energy stresses, such as those caused carbon, phosphorus, or oxygen starvation, addition oxidative micouplers to growth medium; (ii) environmental acid, ethanol, heat, salt stress. Site-directed mutagenesis has shown Per-Arnt-Sim (PAS) domain RsbP, at least defining residue within domain, are indeed important for In contrast, kinase RsbT is essential response, suggesting modulation this route signals enter branch. RsbU, SpoIIE phosphatases each contain additional domains regulate phosphatase in inputs, appears be an emerging theme stress-signaling PP2C both prokaryotic eukaryotic organisms. Interestingly, components partner-switching mechanism appear widely distributed among eubacteria. some cases, Synechocystis sp. strain PCC 6803, all switch present manifest predicted activities vitro. E. coli RsbV ortholog YrbB, no obvious partner exists genome.