Protection against neurodegeneration with low-dose methylene blue and near-infrared light.

摘要: Neurons are metabolically protected against degeneration using low-level methylene blue and near-infrared light interventions. Both of these novel interventions act by a cellular mechanism involving enhancement the electron transport chain in mitochondria, which promotes energy metabolism neuronal survival (Gonzalez-Lima et al., 2014). Methylene preferentially enters mitochondria after systemic administration, at low-doses forms an cycling redox complex that donates electrons to mitochondrial chain. Low-level applied transcranially delivers photons cortical neurons accepted cytochrome oxidase, causes increased cell respiration cerebral blood flow. Breakthrough vivo studies with suggest targeting may be beneficial for protection different types neurodegenerative disorders. The purpose this paper is provide update on mechanisms mediating neuroprotective effects low doses light, argue neurotherapeutic benefits two share same action based stimulation respiration. Presented first explanation biochemical low-dose as cycler transport. second biophysical photon donor oxidase also serves stimulate We finish comparison how they common similar properties such transfer, hormetic dose-responses, enhanced capacity oxidative metabolic production, serve protect nervous tissue from degeneration.