Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.
作者： Douglas Fambrough , Kimberly McClure , Andrius Kazlauskas , Eric S Lander
DOI: 10.1016/S0092-8674(00)80785-0
关键词:
摘要: Abstract We sought to explore the relationship between receptor tyrosine kinase (RTK) activated signaling pathways and transcriptional induction of immediate early genes (IEGs). Using global expression monitoring, we identified 66 fibroblast IEGs induced by platelet-derived growth factor β (PDGFRβ) signaling. Mutant receptors lacking binding sites for activation PLCγ, PI3K, SHP2, RasGAP still retain partial ability induce 64 these IEGs. Removal Grb2-binding site further broadly reduces induction. These results suggest that diverse exert overlapping effects on IEG Interestingly, a mutant restores RasGAP-binding promotes an independent group genes, normally interferons. Finally, compare PDGFRβ 1; each induces essentially identical in fibroblasts.
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