Comparison of rapid detection methods for influenza A virus and their value in health-care management of institutionalized geriatric patients.

摘要: Respiratory specimens from 160 geriatric patients with suspected influenza illness were used to evaluate the abilities of two enzyme immunoassays (EIAs; Directigen FLU-A [Becton Dickinson Microbiology Systems, Cockeysville, Md.] and Prima EIA [Baxter/Bartels Diagnostics, Inc., Issaquah, Wash.]) direct immunofluorescence testing (immunofluorescence assay [IFA]) identify A virus. In comparison culture isolation, sensitivities specificities IFA, FLU-A, 92.5 97.2%, 86.8 99.1%, 98.1%, respectively. contrast EIA, IFA was labor intensive required a high degree technical expertise, results difficult interpret. These factors may preclude use for large numbers specimens. retrospective epidemiologic survey infection done in six institutions which had either rapid or alone. Preventable cases virus ranged 9 38% all facilities only not instituted amantadine prophylaxis. The specimen is recommended as an adjunct isolation identification Use combination these methods permits timely administration appropriate antiviral therapy control measures, while it also antigenic surveillance circulating strains, necessary present vaccine efficacy evaluations creation future effective formulations.