Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats
作者： O. B. Akinola , S. A. Biliaminu , O. G. Adedeji , B. S. Oluwaseun , O. M. Olawoyin
DOI: 10.1111/AND.12512
关键词:
摘要: Exposure to either environmental toxicants or chronic hyperglycaemia could impair male reproductive function. However, the extent which exposure such toxicants, in presence of pre-existing metabolic dysfunction, affect reproduction is unclear. Streptozotocin-induced diabetic Wistar rats (12 weeks old) were exposed oral aluminium chloride at 250 ppm for 30 days; followed by evaluation caudal epididymal sperm count and motility, assay serum follicle stimulating hormone (FSH), testosterone (T) oestradiol; assessment testicular histology. Moreover, blood glucose was evaluated oxidase method. In treated with streptozotocin (STZ) (Al) alone, erosion parenchyma stroma observed. This effect most severe simultaneously Al; coupled reduced that least this (STZ+Al) group (18.75 × 10(6) ml(-1) ) compared controls (61.25 × 10(6) ; P < 0.05), STZ Al group. these perturbations (in STZ+Al group) associated motility significantly FSH (P < 0.05); but elevated T oestradiol (P < 0.05), control. These suggest diabetes-induced lesion exacerbated simultaneous toxicity rats.
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