Knock-out mouse models of proprotein convertases: unique functions or redundancy?

摘要: The members of the proprotein convertase family play a central role in processing and/or activation various protein precursors involved many physiological processes and pathologies. proteolysis these that occur at basic residues within general motif (K/R)-(X)-(K/R) is mediated by convertases PC1/3, PC2, Furin, PACE4, PC4, PC5 PC7, whereas hydrophobic performed S1P/SKI-1 NARC-1/PCSK9 seems to prefer cleavages LVFAQSIP. Here we provide comprehensive overview their remarkable complex roles as revealed disruption genes individually using generalized or conditional approaches.