Ultrastructural changes associated with renin secretion from the juxtaglomerular apparatus of mice.

摘要: Thin sections and freeze-fracture replicas were used to investigate the ultrastructural changes associated with renin secretion from juxtaglomerular part of afferent arteriole male mice. Adrenalectomized animals in which was stimulated by furosemide application bleeding also studied. Exocytosis mature electron-dense granules found all experimental groups. Before extrusion, region granule facing cell membrane changed, vesicular and/or stacked membrane-like profiles a small local protrusion appearance of. Concomitantly, punctuate sites fusion between membranes observed. Later, unaltered amorphous, altered content released omega-shaped cavities into extracellular space. In alteration extrusion several closely apposed reminiscent compound exocytosis. Coated pits frequently seen, suggesting specific retrieval former membrane. The collapsing silhouette depleted very rarely took form saccule whose narrow membrane-bounded neck continuous