Whole blood for hemostatic resuscitation of major bleeding.

摘要: Recent combat experience reignited interest in transfusing whole blood (WB) for patients with life-threatening bleeding. US Army data indicate that WB transfusion is associated improved or comparable survival compared to resuscitation components. These complement randomized controlled trials platelet (PLT)-containing products stored at 4°C have superior hemostatic function, based on reduced bleeding and functional measures of hemostasis, PLT-containing 22°C. rarely available civilian hospitals as a result transfused hemorrhagic shock. developments suggest impediments availability can be overcome, specifically the misconceptions must ABO specific, cannot leukoreduced maintain PLTs, finally cold storage causes loss PLT function. Data use low anti-A anti-B titer group O safe universal donor, PLT-sparing filters, retains function during 15 days storage. The understanding these perceived barriers are not insurmountable will improve facilitate its use. In addition, there logistic economic advantages WB-based component therapy low-titer up merits further study compare efficacy safety current approaches all