Structural homology of DNA polymerase beta from various mammalian cells.
作者： K. Tanabe , M. Yamaguchi , A. Matsukage , T. Takahashi
DOI: 10.1016/S0021-9258(19)69729-2
关键词:
摘要: DNA polymerase beta was purified from various mammalian cells, i.e. mouse myeloma, rat liver, ascites hepatoma rabbit pig and calf thymus cells. The apparent molecular weights of the polypeptides composing these enzymes were all about 40,000, as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Moreover, tryptic peptide maps after radioiodination with 125I indicated that structures basically identical. No difference detected in enzymes, only a few 22 spots fingerprint enzyme not enzyme. Furthermore, beta's normal malignant cells differed one spot.
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