Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle.
作者： Andre Marette
DOI: 10.2741/1137
关键词:
摘要: Glucose transport across the cell surface is a key regulatory step for glucose metabolism in skeletal muscle. Both insulin and exercise increase into myofibers through transporter (GLUT) proteins. Skeletal muscle expresses several members of GLUT family but GLUT4 considered main "regulatable" isoform that modulated by contraction. rate can be stimulated either recruitment units from intracellular storage vesicles or activation transporters. Insulin activates translocation complex signaling cascade involving both lipid kinase phosphatidylinositol 3-kinase proto-oncoprotein c-Cbl. Contraction, on other hand, appears to trigger at least part metabolite-sensing 5'-AMP-activated protein kinase. Furthermore, recent studies suggest p38 MAP represents point convergence pathways utilized contraction surface. This review will summarize our current knowledge these alternative regulation
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