Ranibizumab Plus Combined Surgery for Treatment of Neovascular Glaucoma with Vitreous Hemorrhage

摘要: Background: Neovascular glaucoma (NVG) is a refractory glaucoma. The management of NVG very difficult, and it more difficult when combined with vitreous hemorrhage. aim this study was to investigate the effects ranibizumab plus surgery for Methods: A total 26 eyes patients hemorrhage were recruited in study. aged from 36 63 years mean age 51.97 ± 7.60 years. intraocular pressure (IOP) 46.38 5.75 mmHg (1 = 0.133 kPa) while being treated maximum medical therapy. best-corrected visual acuities converted logarithm minimum angle resolution (logMAR BCVA) 2.62 0.43. All underwent intravitreal injection 0.5 mg (0.05 ml) pars plana vitrectomy (PPV), lensectomy (PPL) preserved anterior capsule, panretinal photocoagulation (PRP), trabeculectomy (intravitreal [IVR] + PPV PPL PRP trabeculectomy). IOP logMAR BCVA main outcome measures Results: follow-up period 12 months. postoperative IOPs 26.38 3.75 mmHg, 21.36 3.32 18.57 3.21 16.68 2.96 respectively at 7 days, 1 month, 3 months, months after trabeculectomy. At last follow-up, significantly lower than preoperative one ( t 6.612, P 0.001). trabeculectomy, 1.30 0.36, 1.29 0.37, 0.39, 1.26 0.29, respectively. improved, difference statistically significant compared 6.133, 0.002). improved 22 (84.62%), remained stable 4 (15.38%). neovascularization iris regressed all days injection. No serious complications occurred during Conclusions: IVR can control well improve without severe complication