Systematic review of studies of the effect of hyperoxia on coronary blood flow.

摘要: Background International guidelines recommend the routine use of oxygen in initial treatment myocardial infarction, yet it is uncertain what effect this might have on physiologic and clinical outcomes. Methods We undertook a systematic search Medline, Cochrane Database Systematic Reviews, EMBASE, CINHAL using key words "oxygen," "coronary blood flow," "hyperoxia," circulation" to identify human studies involving measure coronary flow while breathing room air. The primary outcome was flow; secondary outcomes included vascular resistance consumption. Results From 2,072 potential publications, there were 6 from 4 publications that met inclusion criteria, with healthy subjects 61 cardiac disease. It not possible undertake meta-analysis due methodological limitations. In studies, high-concentration therapy resulted hyperoxia, range mean Pao 2 273 425 mm Hg. Hyperoxia caused significant reduction (mean change −7.9% −28.9%, n=6 studies). increase 21.5% 40.9%, n=4 studies) consumption −15.3% −26.9%, n=3 Conclusions causes marked These effects may cause harm are relevant other disorders.