Functional outcome in patients with advanced head and neck cancer: surgery and reconstruction with free flaps versus primary radiochemotherapy

摘要: The objective was to compare functional outcome in patients with advanced head and neck cancer (HNC) treated (a) surgical resection reconstruction microvascular free flaps (MVFF) followed by radiochemotherapy versus (b) primary (RCT) on the basis of International Classification Functioning, Disability Health (ICF) from WHO. This a cross-sectional, multi-institutional study. measures included ICF Core Sets for HNC, EORTC-QLQ, modules c30 + hn35 University Washington-Quality life Questionnaire (UW-QOL). Analyses descriptive statistics, ranking exercises, regression analyses cumulative logit model; 27 were MVFF 22 RCT. Global Quality scores suggested slightly better approach. majority categories (81/93, 87%) did not show difference between two treatment approaches. In remaining 12 categories, n = 3 body structures more affected group, while functions, 6 activities/participations problematic RCT group. oral swallowing weight maintenance functions as well social relationships, acquiring job, economic self-sufficiency. addition, nine contextual environmental factors relevant Both approaches seemed appropriate HNC perspective outcome. influence modalities lives survivors needs be explored further. order guide rehabilitation according patients' needs, offers multidimensional view comprising structures, activities participation life.