Combination therapy for treating hepatitis c virus infection

作者: Lawrence M. Blatt

DOI:

关键词:

摘要: The present invention provides methods of treating hepatitis C virus (HCV) infection; reducing the incidence complications associated with HCV and cirrhosis liver; viral load, or time to clearance, morbidity mortality in clinical outcomes, patients suffering from infection. generally involve administering individual i) a Type I interferon receptor agonist III agonist; ii) an immunomodulatory agent; iii) inhibitor enzyme.

参考文章(12)
Thomas Hügle, Andreas Cerny, Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C. Reviews in Medical Virology. ,vol. 13, pp. 361- 371 ,(2003) , 10.1002/RMV.397
Jingyu Diao, Aye Aye Khine, Farida Sarangi, Eric Hsu, Caterina Iorio, Lee Anne Tibbles, James R. Woodgett, Josef Penninger, Christopher D. Richardson, X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway Journal of Biological Chemistry. ,vol. 276, pp. 8328- 8340 ,(2001) , 10.1074/JBC.M006026200
Michelle P Walker, Nanhua Yao, Zhi Hong, Promising candidates for the treatment of chronic hepatitis C. Expert Opinion on Investigational Drugs. ,vol. 12, pp. 1269- 1280 ,(2003) , 10.1517/13543784.12.8.1269
Angelika G. Börsch-Haubold, Fulvia Bartoli, Judith Asselin, Thomas Dudler, Ruth M. Kramer, Rafael Apitz-Castro, Steve P. Watson, Michael H. Gelb, Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells Journal of Biological Chemistry. ,vol. 273, pp. 4449- 4458 ,(1998) , 10.1074/JBC.273.8.4449
Christophe Bureau, José Bernad, Nadia Chaouche, Claudine Orfila, Maryse Béraud, Chistophe Gonindard, Laurent Alric, Jean-Pierre Vinel, Bernard Pipy, Nonstructural 3 Protein of Hepatitis C Virus Triggers an Oxidative Burst in Human Monocytes via Activation of NADPH Oxidase Journal of Biological Chemistry. ,vol. 276, pp. 23077- 23083 ,(2001) , 10.1074/JBC.M100698200
Lorena Navarro, Michael David, p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. Journal of Biological Chemistry. ,vol. 274, pp. 35535- 35538 ,(1999) , 10.1074/JBC.274.50.35535
Robert B. Perni, Kevin M. Cottrell, Shawn D. Britt, Janos Pitlik, Inhibitors of serine proteases, particularly hcv ns3-ns4a protease ,(2004)
Robert E. Lanford, Bernadette Guerra, Helen Lee, Devron R. Averett, Brad Pfeiffer, Deborah Chavez, Lena Notvall, Catherine Bigger, Antiviral Effect and Virus-Host Interactions in Response to Alpha Interferon, Gamma Interferon, Poly(I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons Journal of Virology. ,vol. 77, pp. 1092- 1104 ,(2003) , 10.1128/JVI.77.2.1092-1104.2003
Myung-ok Park-Cho, Carl W. Gilbert, Interferon polymer conjugates ,(1994)