Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto
作者： Bruce A. Malcolm , Xiao Tong , Hsueh-Cheng Huang
DOI:
关键词: Stereochemistry 、 Virology 、 Polymerase inhibitor 、 Hcv protease 、 Medicine
摘要: Disclosed are medicaments, pharmaceutical compositions, kits, and methods based on combinations of at least one HCV protease inhibitor polymerase but not HCV-796; for concurrent or consecutive administration in treating ameliorating more symptoms HCV, disorders associated with a subject need thereof.
lens.org 参考文章(12)
Joseph A. Kozlowski, Ling Tong, Neng-Yang Shih, Bandarpalle B. Shankar, Cannabinoid receptor agonists ,(2003)
Lawrence M. Blatt, Combination therapy for treating hepatitis c virus infection ,(2004)
Masahiro C, Kazumasa C, Preventive and therapeutic agent for hepatitis ,(1990)
Atsuhito Yoshida, Hiromasa Hashimoto, Kenji Mizutani, Fused cyclic compounds and medicinal use thereof ,(2002)
George Kukolj, Graham A. McGibbon, Ginette McKercher, Martin Marquis, Sylvain Lefèbvre, Louise Thauvette, Jean Gauthier, Sylvie Goulet, Marc-André Poupart, Pierre L. Beaulieu, Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase. Journal of Biological Chemistry. ,vol. 280, pp. 39260- 39267 ,(2005) , 10.1074/JBC.M506407200
Tarik Asselah, Patrick Marcellin, BILN 2061: a major step toward new therapeutic strategies in hepatitis C Journal of Hepatology. ,vol. 41, pp. 178- 181 ,(2004) , 10.1016/J.JHEP.2004.05.004
Elise Ghiro, Montse Llinas-Brunet, Marc-André Poupart, Murray D. Bailey, Teddy Halmos, Punit Bhardwaj, Jean Rancourt, Nathalie Goudreau, Hepatitis C inhibitor peptide analogs ,(2005)
Scott L. Harbeson, Govinda Rao Bhisetti, David D. Deininger, Roger D. Tung, Luc J. Farmer, Mark A. Murcko, Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease ,(2003)
Hongmei Mo, Liangjun Lu, Tami Pilot-Matias, Ron Pithawalla, Rubina Mondal, Sherie Masse, Tatyana Dekhtyar, Teresa Ng, Gennadiy Koev, Vincent Stoll, Kent D. Stewart, John Pratt, Pam Donner, Todd Rockway, Clarence Maring, Akhteruzzaman Molla, Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro Antimicrobial Agents and Chemotherapy. ,vol. 49, pp. 4305- 4314 ,(2005) , 10.1128/AAC.49.10.4305-4314.2005
Pierre Louis Beaulieu, Gulrez Fazal, George Kukolj, Eric Jolicoeur, James Gillard, Marc-Andre Poupart, Jean Rancourt, Viral Polymerase Inhibitors ,(2007)