Desenvolvimento de comprimidos de AAS 500 mg: influência do Amido 1500 ® na compressão direta

摘要: The present work aims to show the technologic viability in development of AAS 500 mg tablets using direct compression (CD) process. We employed Starch 1500 ® as excipient develop formulations, trying investigate its compression, disintegration, aggregation and lubrication properties. Technologic, physical chemical essays were performed methodologies anticipated pharmacology. Results demonstrated that powder mix showed characteristics free flux good qualities very important for excipients market. interfered disintegration time. formulation with 6,35% proposed this obtained a highest proximity between products Brazilian market