Identification of a novel TMEM106B-ROS1 fusion variant in lung adenocarcinoma by comprehensive genomic profiling

Sai-Hong Ignatius Ou, Samuel J. Klempner, Joel R. Greenbowe, Michele Azada, Alexa B. Schrock, Siraj M. Ali, Jeffrey S. Ross, Philip J. Stephens, Vincent A. Miller, Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib. Journal of Thoracic Oncology. ,vol. 9, pp. 1821- 1825 ,(2014) , 10.1097/JTO.0000000000000368

Alice T. Shaw, Sai-Hong I. Ou, Yung-Jue Bang, D. Ross Camidge, Benjamin J. Solomon, Ravi Salgia, Gregory J. Riely, Marileila Varella-Garcia, Geoffrey I. Shapiro, Daniel B. Costa, Robert C. Doebele, Long Phi Le, Zongli Zheng, Weiwei Tan, Patricia Stephenson, S. Martin Shreeve, Lesley M. Tye, James G. Christensen, Keith D. Wilner, Jeffrey W. Clark, A. John Iafrate, Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer The New England Journal of Medicine. ,vol. 371, pp. 1963- 1971 ,(2014) , 10.1056/NEJMOA1406766

Marka Van Blitterswijk, Bianca Mullen, Alexandra M Nicholson, Kevin F Bieniek, Michael G Heckman, Matthew C Baker, Mariely DeJesus-Hernandez, NiCole A Finch, Patricia H Brown, Melissa E Murray, Ging-Yuek R Hsiung, Heather Stewart, Anna M Karydas, Elizabeth Finger, Andrew Kertesz, Eileen H Bigio, Sandra Weintraub, Marsel Mesulam, Kimmo J Hatanpaa, Charles L White III, Michael J Strong, Thomas G Beach, Zbigniew K Wszolek, Carol Lippa, Richard Caselli, Leonard Petrucelli, Keith A Josephs, Joseph E Parisi, David S Knopman, Ronald C Petersen, Ian R Mackenzie, William W Seeley, Lea T Grinberg, Bruce L Miller, Kevin B Boylan, Neill R Graff-Radford, Bradley F Boeve, Dennis W Dickson, Rosa Rademakers, None, TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia Acta Neuropathologica. ,vol. 127, pp. 397- 406 ,(2014) , 10.1007/S00401-013-1240-4

Sai-Hong Ignatius Ou, Michele Azada, David J. Hsiang, June M. Herman, Tatiana S. Kain, Christina Siwak-Tapp, Cameron Casey, Jie He, Siraj M. Ali, Samuel J. Klempner, Vincent A. Miller, Next-Generation Sequencing Reveals a Novel NSCLC ALK F1174V Mutation and Confirms ALK G1202R Mutation Confers High-Level Resistance to Alectinib (CH5424802/RO5424802) in ALK-Rearranged NSCLC Patients Who Progressed on Crizotinib Journal of Thoracic Oncology. ,vol. 9, pp. 549- 553 ,(2014) , 10.1097/JTO.0000000000000094

Akihiko Yoshida, Koji Tsuta, Susumu Wakai, Yasuhito Arai, Hisao Asamura, Tatsuhiro Shibata, Koh Furuta, Takashi Kohno, Ryoji Kushima, Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers Modern Pathology. ,vol. 27, pp. 711- 720 ,(2014) , 10.1038/MODPATHOL.2013.192

Massimiliano Stagi, Zoe A. Klein, Travis J. Gould, Joerg Bewersdorf, Stephen M. Strittmatter, Lysosome size, motility and stress response regulated by Fronto-Temporal Dementia modifier TMEM106B Molecular and Cellular Neuroscience. ,vol. 61, pp. 226- 240 ,(2014) , 10.1016/J.MCN.2014.07.006

John Q. Trojanowski, Virginia M. Y. Lee, Vivianna Van Deerlin, Alice S. Chen-Plotkin, Michael D. Gallagher, Eunran Suh, Murray Grossman, Lauren Elman, Leo McCluskey, John C. Van Swieten, Safa Al-Sarraj, Manuela Neumann, Ellen Gelpi, Bernardino Ghetti, Jonathan D. Rohrer, Glenda Halliday, Christine Van Broeckhoven, Danielle Seilhean, Pamela J. Shaw, Matthew P. Frosch, Irina Alafuzoff, Anna Antonell, Nenad Bogdanovic, William Brooks, Nigel J. Cairns, Johnathan Cooper-Knock, Carl Cotman, Patrick Cras, Marc Cruts, Peter P. De Deyn, Charles DeCarli, Carol Dobson-Stone, Sebastiaan Engelborghs, Nick Fox, Douglas Galasko, Marla Gearing, Ilse Gijselinck, Jordan Grafman, Päivi Hartikainen, Kimmo J. Hatanpaa, J. Robin Highley, John Hodges, Christine Hulette, Paul G. Ince, Lee-Way Jin, Janine Kirby, Julia Kofler, Jillian Kril, John B. J. Kwok, Allan Levey, Andrew Lieberman, Albert Llado, Jean-Jacques Martin, Eliezer Masliah, Christopher J. McDermott, Ann McKee, Catriona McLean, Simon Mead, Carol A. Miller, Josh Miller, David G. Munoz, Jill Murrell, Henry Paulson, Olivier Piguet, Martin Rossor, Raquel Sanchez-Valle, Mary Sano, Julie Schneider, Lisa C. Silbert, Salvatore Spina, Julie van der Zee, Tim Van Langenhove, Jason Warren, Stephen B. Wharton, Charles L. White III, Randall L. Woltjer, TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions Acta Neuropathologica. ,vol. 127, pp. 407- 418 ,(2014) , 10.1007/S00401-013-1239-X

Yoshiyuki Suehara, Maria Arcila, Lu Wang, Adnan Hasanovic, Daphne Ang, Tatsuo Ito, Yuki Kimura, Alexander Drilon, Udayan Guha, Valerie Rusch, Mark G. Kris, Maureen F. Zakowski, Naiyer Rizvi, Raya Khanin, Marc Ladanyi, Identification of KIF5B-RET and GOPC-ROS1 Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions Clinical Cancer Research. ,vol. 18, pp. 6599- 6608 ,(2012) , 10.1158/1078-0432.CCR-12-0838

Alexander Drilon, Lu Wang, Maria E. Arcila, Sohail Balasubramanian, Joel R. Greenbowe, Jeffrey S. Ross, Phil Stephens, Doron Lipson, Vincent A. Miller, Mark G. Kris, Marc Ladanyi, Naiyer A. Rizvi, Broad, Hybrid Capture–Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches Clinical Cancer Research. ,vol. 21, pp. 3631- 3639 ,(2015) , 10.1158/1078-0432.CCR-14-2683

Sai-Hong Ignatius Ou, Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy? Journal of Clinical Pathology. ,vol. 66, pp. 839- 846 ,(2013) , 10.1136/JCLINPATH-2012-201296