Detection of circulating tumor DNA in patients with advanced non-small cell lung cancer

作者: Yu Yao , Jinghao Liu , Lei Li , Yuan Yuan , Kejun Nan

DOI: 10.18632/ONCOTARGET.12883

关键词:

摘要: Circulating tumor DNA (ctDNA) isolated from plasma has great potential in identification of gene mutation non-small cell lung cancers (NSCLC), which is a non-invasive technique and can avoid the inherent shortcomings tissue biopsy. However ability NGS to detect ctDNA not been broadly explored. To assess diagnostic for total profile, including single nucleotide variations (SNVs), insertions deletions (indels) rearrangements, we performed targeted sequencing approach screen NSCLC related driver mutations both biopsies matched blood samples 39 advanced patients China. The sensitivity EGFR, KRAS, PIK3CA rearrangements detected was 70.6%, 75%, 50% 60%, respectively overall concordance between 78.21%. Our data provide evidence that likely become an alternative source cancer-related profiling offers promising perspective on precise diagnostics may serve as feasible option clinical monitoring patients.

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