Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK
作者： Alice T. Shaw , Beow Y. Yeap , Mari Mino-Kenudson , Subba R. Digumarthy , Daniel B. Costa
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摘要: Purpose The EML4-ALK fusion oncogene represents a novel molecular target in small subset of non–small-cell lung cancers (NSCLC). To aid identification and treatment these patients, we examined the clinical characteristics outcomes patients who had NSCLC with without EML4-ALK. Patients Methods were selected for genetic screening on basis two or more following characteristics: female sex, Asian ethnicity, never/light smoking history, adenocarcinoma histology. was identified by using fluorescent situ hybridization ALK rearrangements confirmed immunohistochemistry expression. EGFR KRAS mutations determined DNA sequencing. Results Of 141 tumors screened, 19 (13%) mutant, 31 (22%) 91 (65%) wild type (WT/WT) both EGFR. Compared mutant WT/WT cohorts, significantly younger (P < .001 ...
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