Nonsuppressible insulin-like activity (NSILA) of human serum. V. Hypoglycaemia and preferential metabolic stimulation of muscle by NSILA-S.

摘要: 10 mU of NSILA-S, as determined by the fat pad assay, lowered blood glucose and free fatty acids adrenalectomized rate for a much longer period than crystalline insulin. NSILA-S was not measurably inactivated liver during 2 h cyclical perfusion, whereas insulin rapidly lost activity with half-life 42 min. 6 injected intravenously stimulated incorporation [6-14C] into diaphragm streptozotocin-diabetic rats to greater extent insulin, their effects on carbon 14 were equal. When intraperitoneally in maximal doses normal both agents [U-14C] adipose tissue same extent. There no potentiation either agent other vitro, indicating that they affect transport site cell membrane. Insulin influenced metabolism fasted-refed manner. It is concluded i.v. more effective vivo comparable because it liver. Furthermore, seems have particular affinity receptors muscle This may be an additional factor protecting from inactivation tissues.