Ethyl 1-(2,4-dichloro­benz­yl)-4-oxo-7-trifluoro­meth­yl-1,4-dihydro­quinoline-3-carboxyl­ate

作者: Hoong-Kun Fun , Chin Wei Ooi , B. Garudachari , Arun M. Isloor , Gurumurthy Hegde

DOI: 10.1107/S1600536812001249

关键词:

摘要: In the title compound, C20H14Cl2F3NO3, trifluromethyl group is disordered over two sets of sites in a 0.784 (10):0.216 (10) ratio. The quinoline ring system essentially planar with maximum deviation 0.058 (2) A for N atom and forms dihedral angles 89.23 (11) 8.13 (17)°, respectively mean planes benzene carboxyl­ate group. crystal, pairs weak C—H⋯O C—H⋯F hydrogen bonds link mol­ecules into centrosymmetric dimers. crystal structure further stabilized by π–π [centroid–centroid distance = 3.624 (2) A] inter­actions.

参考文章(9)
Yeh-Long Chen, Hsien-Ming Hung, Chih-Ming Lu, Kuang-Chieh Li, Cherng-Chyi Tzeng, Synthesis and anticancer evaluation of certain indolo[2,3-b]quinoline derivatives. Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 6539- 6546 ,(2004) , 10.1016/J.BMC.2004.09.025
Kirandeep Kaur, Meenakshi Jain, Ravi P. Reddy, Rahul Jain, Quinolines and structurally related heterocycles as antimalarials European Journal of Medicinal Chemistry. ,vol. 45, pp. 3245- 3264 ,(2010) , 10.1016/J.EJMECH.2010.04.011
Sumesh Eswaran, Airody Vasudeva Adhikari, Imran H. Chowdhury, Nishith K. Pal, K.D. Thomas, New quinoline derivatives: synthesis and investigation of antibacterial and antituberculosis properties. European Journal of Medicinal Chemistry. ,vol. 45, pp. 3374- 3383 ,(2010) , 10.1016/J.EJMECH.2010.04.022
Ramya V. Shingalapur, Kallappa M. Hosamani, Rangappa S. Keri, Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles European Journal of Medicinal Chemistry. ,vol. 44, pp. 4244- 4248 ,(2009) , 10.1016/J.EJMECH.2009.05.021
George M. Sheldrick, A short history of SHELX Acta Crystallographica Section A. ,vol. 64, pp. 112- 122 ,(2008) , 10.1107/S0108767307043930
Anthony L. Spek, Structure validation in chemical crystallography Acta Crystallographica Section D-biological Crystallography. ,vol. 65, pp. 148- 155 ,(2009) , 10.1107/S090744490804362X
Frank H. Allen, Olga Kennard, David G. Watson, Lee Brammer, A. Guy Orpen, Robin Taylor, Tables of bond lengths determined by X-ray and neutron diffraction. Part 1. Bond lengths in organic compounds Journal of The Chemical Society-perkin Transactions 1. ,(1987) , 10.1039/P298700000S1
Hoong-Kun Fun, Suhana Arshad, B. Garudachari, Arun M. Isloor, M. N. Satyanarayan, 4-(4-Methyl-piperazin-1-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-7-(trifluoro-meth-yl)quinoline. Acta Crystallographica Section E-structure Reports Online. ,vol. 67, ,(2011) , 10.1107/S1600536811044370
Li-Chen Chou, Meng-Tung Tsai, Mei-Hua Hsu, Sheng-Hung Wang, Tzong-Der Way, Chi-Hung Huang, Hui-Yi Lin, Keduo Qian, Yizhou Dong, Kuo-Hsiung Lee, Li-Jiau Huang, Sheng-Chu Kuo, Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents Journal of Medicinal Chemistry. ,vol. 53, pp. 8047- 8058 ,(2010) , 10.1021/JM100780C