Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles
作者： Ramya V. Shingalapur , Kallappa M. Hosamani , Rangappa S. Keri
DOI: 10.1016/J.EJMECH.2009.05.021
关键词: Enterococcus faecalis 、 Chemical synthesis 、 Staphylococcus aureus 、 Antibacterial agent 、 Escherichia coli 、 Antimicrobial 、 Stereochemistry 、 Microbiology 、 Candida albicans 、 Klebsiella pneumoniae 、 Chemistry
摘要: A new series of novel 5-(nitro/bromo)-styryl-2-benzimidazoles (1-12) has been synthesized by simple, mild and efficient synthetic protocol attempted condensation 5-(nitro/bromo)-o-phenylenediamine with trans-cinnamic acids in ethylene glycol. Screening for vitro anti-tubercular activity against Mycobacterium tuberculosis H(37) Rv, anti-bacterial Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae bacterial strains anti-fungal Candida albicans Asperigillus fumigatus fungal were carried out. Compounds 5, 7, 8, 9, 11 showed higher compounds 10, 11, 12 have proved to be effective MIC (microg/ml) emerged as lead molecules showing excellent activities a panel microorganisms. All characterized using IR, (1)H, (13)C NMR, GC-MS elemental analysis.
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