Clinical epidemiology of ALS in Liguria, Italy

摘要: AbstractOur objective was to assess the incidence and trends of amyotrophic lateral sclerosis (ALS) in Liguria, a north-west region Italy, utilizing prospective design. Liguria (1,615,064 residents 2010) is site multicentre-multisource population based registry called LIGALS (Liguria Amyotrophic Lateral Sclerosis Registry). All incident ALS cases during period 2009–2010 were enrolled followed up. Cases identified using several concurrent sources. diagnosis on revised El Escorial criteria. One hundred four enrolled, generating an annual crude 3.22/100,000 (95% CI 2.66−3.90), with male/female ratio 1.34. The standardized incidence, age gender adjusted 2001 Italian population, 2.51. At last observation 1 March 2012, 45% patients registered had died, median survival 45 months from symptoms onset. According capture-recapture estimation, three unobserv...