No beneficial effects of vitamin D supplementation on muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial.

摘要: Context: Impairments of muscle function and strength in patients with primary hyperparathyroidism (PHPT) are rarely addressed, although decreased may contribute to increased fracture risk. Objective: We aimed assess the changes strength, function, postural stability, quality life (QoL), well-being during treatment vitamin D or placebo before after parathyroidectomy (PTX) PHPT patients. Design: A randomized placebo-controlled trial. Patients: included 46 patients, mean age 58 (range 29–77) years 35 (76%) were women. Interventions: Daily 70 mg (2800 IU) cholecalciferol for 52 weeks. Treatment was administered 26 weeks PTX continued PTX. Main outcome measures: Changes QoL measures function. Results: Preoperatively, 25-hydroxyvitamin (25OHD) significantly (50–94 nmol/l) compared (57–52 nmol/l). did not measure any beneficial effects supplementation regarding well-being, QoL, In all we measured marked improvements (P!0.01), knee flexion extension (P!0.001), tests (P!0.01) surgical cure. Postural stability improved standing eyes closed (P!0.05), but open (P!0.05). Conclusions: Patients 25OHD levels around 50 nmol/l benefit from concerning QoL. Independent preoperative levels, these parameters.