Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC).

摘要: Abstract Backround Fine particulate air pollution (PM2.5) is known to contribute cardiorespiratory mortality but it not clear how PM2.5 oxidative burden (i.e. the ability of cause stress) may influence long-term risk. Methods We examined relationship between and cause-specific in Ontario, Canada. Integrated samples were collected from 30 provincial monitoring sites 2012 2013. The potential (% depletion/µg) regional was measured as filter extracts deplete antioxidants (glutathione ascorbate) a synthetic respiratory tract lining fluid. calculated product mass concentrations estimates potential. In total, this study included 193,300 people who completed Canadian long-form census 1991 lived within 5 km site where measured. Deaths occurring 2009 identified through record linkages Cox proportional hazard models used estimate ratios (and 95% confidence intervals) for interquartile changes exposure adjusting individual-level covariates indirect-adjustment smoking obesity. Results Glutathione-related associated with mortality. For lung cancer specifically, metric 12% (95% CI: 5.0–19) increased risk whereas 5.0% 0.1, 10) increase observed PM2.5. Indirect adjustment obesity decreased ratio glutathione-related remained significantly elevated (HR=1.07, 1.005, 1.146). Ascorbate-related Conclusions Our findings suggest that be more strongly than concentrations.