A case-control study of genotoxicity endpoints in patients with papillary thyroid cancer.
作者： Marko Gerić , Renato Janušić , Božena Šarčević , Vera Garaj-Vrhovac
DOI: 10.1016/J.MRGENTOX.2015.05.006
关键词:
摘要: Abstract Thyroid cancer is one of the fastest growing types worldwide. Using cytokinesis-block micronucleus (CBMN) and comet assays, we performed a case-control study 23 untreated papillary thyroid (PTC) patients healthy volunteers. PTC showed higher basal DNA damage in peripheral blood lymphocytes. The CBMN assay indicated that numbers micronuclei, nuclear buds, nucleoplasmic bridges among cases were 2.67-, 2.79-, 7.72-fold higher, respectively, than controls ( p
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