Cell adhesion and morphogenesis: the regulator hypothesis

摘要: A sequence for the genetic and molecular regulation of morphogenesis is proposed in terms regulator hypothesis which intended to provide a specific framework relating developmental genetics evolution. The derives from an analysis interactive morphogenetic roles primary processes cell adhesion, movement, embryonic induction during regulative development. According hypothesis, genes adhesion molecules (CAMs) are expressed schedules that prior largely independent those cytodifferentiation. CAMs act as regulators overall patterns movements essential inductive sequences or early milieu-dependent differentiations. It that, evolution, natural selection eliminates organisms variants CAM gene expression both result interruptions sequence. Under this assumption, more than one (but not all) combinations these two variables will lead stabilization order body plan variety species. Moreover, small variations pattern action regulatory selected against could large changes animal form within relatively short periods evolutionary time. experimental bases reviewed here properties their known spatio-temporal embryogenesis.