Cyanide is a product of the catalase-mediated oxidation of the alcohol deterrent agent, cyanamide.
作者： Frances N. Shirota , Eugene G. Demaster , Herbert T. Nagasawa
DOI: 10.1016/0378-4274(87)90160-3
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摘要: Abstract Cyanide was detected as a product of cyanamide oxidation by bovine liver catalase in vitro under conditions that also produced an active aldehyde dehydrogenase (A1DH) inhibitor. formation directly related to both and concentrations dependent on incubation time. The apparent K m for this reaction 172 μM. blocked ethanol, known substrate Compound I. toxic effects the dog, species with limited capacity conjugate N -acetylation, may be causally enhancement catalase-mediated pathway metabolism.
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