Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance.

摘要: Mph1 is a member of the conserved FANCM family DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, cancer predisposition syndrome humans. Here, we identify Mte1 as novel interactor helicase Saccharomyces cerevisiae. In vitro, (Mph1-associated telomere protein 1) binds directly to with preference for branched molecules such D loops and fork structures. addition, stimulates regression activities while inhibiting ability dissociate recombination intermediates. Deletion MTE1 reduces crossover suppresses sensitivity mph1Δ mutant cells replication stress. interdependently colocalize at damage-induced foci dysfunctional telomeres, deletion results elongated telomeres. Taken together, our data indicate plays role regulation recombination, response stress, maintenance.