Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1
作者： Xiaoyu Xue , Alma Papusha , Koyi Choi , Jaclyn N. Bonner , Sandeep Kumar
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摘要: We identified Mte1 (Mph1-associated telomere maintenance protein 1) as a multifunctional regulator of Saccharomyces cerevisiae Mph1, member the FANCM family DNA motor proteins important for replication fork repair and crossover suppression during homologous recombination. show that interacts with Mph1 species resemble D loop formed Biochemically, stimulates Mph1-mediated regression branch migration in model substrate. Consistent this activity, genetic analysis reveals functions associated MHF complex repair. Surprisingly, antagonizes D-loop-dissociative activity Mph1-MHF exerts procrossover role mitotic further influence on activities requires its binding to DNA. Thus, differentially regulates achieve distinct outcomes recombination
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